FAQs

JScreen FAQs: Questions About Genetic Testing

JScreen is a not-for-profit at-home education and carrier screening program for Jewish genetic diseases. The goal of the program is to give individuals and families easy access to information and to allow testing to be done conveniently from home. Testing is performed by a certified laboratory and results are reviewed and reported to participants by genetic counselors. In some states, test results must be reviewed and reported by a specific healthcare provider, and if so, JScreen genetic counselors will work with the provider to ensure you receive your results and any needed follow-up in a timely manner.
Other screening programs require a visit to a community screening event, family physician’s office or medical center. With JScreen, eligible participants can learn about the program and screen from the comfort of their homes.
Our panel includes more than 100 genetic diseases, and includes those that are commonly found the Jewish population.
JScreen genetic testing includes more than 100 diseases and includes those that are predominantly found in the Ashkenazi, Sephardic, or Mizrahi Jewish populations. Most of the diseases are inherited in a recessive pattern, meaning that a child can only have the condition if both parents carry the non-working gene for that condition. People who are carriers do not have symptoms because they only have one copy of the non-working gene. Each child of two carrier parents has a 25% chance of inheriting two copies of the non-working gene and having the condition.

JScreen also screens all women for Fragile X syndrome. (For more information see questions below.)

Fragile X syndrome is a condition that causes a spectrum of developmental and behavioral problems, which tend to be more severe in males. For more information on Fragile X syndrome, click here.
Fragile X syndrome is inherited differently than the other diseases on JScreen’s panels. Women who are carriers have a 50% chance to have an affected child. (Of note, boys symptoms are usually more severe than girls.) Males can be carriers for Fragile X, but it is only when the woman passes on the genetic change that a child is at risk to be affected.

If you and your partner are considering screening, but only want one person to be screened, we suggest women have the screening done so they can be tested for Fragile X.

No, we do not do testing to determine where a person’s ancestors originated.
No, JScreen is an independent not-for-profit program focusing on carrier screening for genetic diseases common in the Jewish population. Both programs allow participants to screen at home, but JScreen’s program is led by medical professionals at an academic medical center and provides specialized genetic counseling follow-up by phone or video-conferencing for people who are identified as carriers.
JScreen is a not-for-profit, university-based program specializing in carrier screening for genetic diseases common in the Jewish population. Our scientific advisory board provides medical oversight for the program All screening tests are ordered by medical providers as required by law. All samples are run by CLIA-certified laboratories and results are reported by licensed genetic counselors with expertise and training in this specialty area. Your results are stored in a HIPAA-compliant database that meets the highest security standards required by Emory University. JScreen’s team of genetic counselors is led by Emory faculty with more than 30 years of combined experience in the genetic counseling field. Finally, JScreen has partnered with other organizations in the Jewish community. Click here for a list.
No. The JScreen genetic screening panels are geared toward reproductive risks, not personal health risks. If you are interested in learning more about breast cancer risks in the Jewish population or if you have specific family history concerns, please contact the Sharsheret program at http://www.sharsheret.org
No. The JScreen genetic testing panels test for carriers of recessive single gene disorders. Your risk for having a child with a chromosomal abnormality like Down Syndrome is not related to your ethnic background. Contact your OB/GYN to discuss the availability of screening for Down Syndrome and other chromosomal abnormalities during pregnancy.
We’re appreciative of our community’s support for our efforts with JScreen. Please email giving@jscreen.org to ask how you can contribute, or click on the “Donate” button at the top of the page.
Please help us spread the work about JScreen to your family, friends and community. Share our website at http://www.jscreen.org/ and encourage your friends and family to follow us on our social media channels:

The JScreen staff can send a representative to give a presentation at an event or meeting in your community. Email us at events@jscreen.org about organizing an event in your area.

About the Test

No. In DTC testing, people order and receive their results directly, without genetic education prior to testing, physician input, or genetic counseling to explain their results. With JScreen, your doctor and our genetic counselors are involved throughout the process.

There are 4 easy steps to obtaining a kit from JScreen:
Step 1:
Request a kit from JScreenorg. We will contact your physician to obtain medical approval.

Step 2: Register
Receive a JScreen kit in the mail, along with instructions for collecting your sample.

Step 3: Submit
Use the kit to send a saliva specimen to the laboratory in a prepaid envelope.

Step 4: Results
In roughly three weeks, you will be contacted by our clinical team when your results are complete.

Screening is done through a saliva sample that the participant collects at home and ships to the testing laboratory. Genetic testing is done on DNA from the saliva sample.
Yes. The DNA that comes from blood is the same as the DNA from saliva, so the accuracy is the same.
Saliva samples are convenient and less invasive than drawing blood. However, there is a small chance that JScreen may require a recollection due to insufficient DNA or the quality of DNA in your sample. All samples undergo a rigorous quality control process, and a small percentage of saliva samples do not pass all quality point checks. If this happens, JScreen will contact you to arrange a recollection. Please click here to watch a video on how to collect your sample and reduce your chances of needing a recollection.
JScreen uses a method called sequencing, which is a thorough look across the gene from beginning to end. A handful of genes on our panel are tested with a different method due to differences in gene structure. This ensures accurate and appropriate testing for those particular conditions.
Yes. Sequencing will detect the majority of carriers in all ethnic groups. In a small percentage of cases, a follow up blood enzyme test will be needed for clarification of carrier status. A JScreen genetic counselor will talk to you more about blood enzyme testing if needed.
The detection rate (rate at which the test can identify carriers) will vary depending on disease. The average detection rate is 94% but many diseases have detection rates of up to 99%.
Learn more about starting the JScreen process of genetic screening today.
Please understand that our program does not advocate screening without appropriate education. To ensure that individuals fully understand the processes and potential outcomes, we request that they watch a brief, engaging educational video. Additionally, participants will be asked to review a detailed consent form. In some cases, JScreen will also obtain an order from your physician. After a person has completed this process, we will be happy to mail them a screening kit.

Eligibility: Who is eligible for genetic testing with JScreen

Yes. In recent years, new diseases have been added to the screening panels. If you have a specific question about your previous screening, contact a JScreen genetic counselor at genetic.counselor@jscreen.org.
Yes! The vast majority of children with these diseases are born to parents who have no family history of the disease. This is because, while there have been generations of healthy carriers in the family, no family members happened to have a child with another carrier. Remember that carriers are healthy and don’t have symptoms of the disease. The only 2 ways to find out you are a carrier are 1) to have an affected child, or 2) to be screened. Screening allows couples to know ahead of time that they are at risk and to take steps toward having healthy children.
No. Each child of two carrier parents is at a 25% risk for having the disease. A carrier couple could have healthy children and then have an affected child. You should ask about updating your screening before each pregnancy.
No. JScreen’s panel includes more than 100 genetic diseases that are commonly found in both the Jewish and general populations. Therefore, the JScreen panel is an option for those with Jewish and non-Jewish ancestry.
Yes. Having even one Jewish grandparent puts you at increased risk for carrying one or more of the Jewish disease genes.
Yes, even if only one member of a couple is Jewish, we recommend that you get screened. Follow-up testing will be recommended if necessary.

Please note that Fragile X syndrome screening is only performed on women. As a result, we recommend that women always be screened, regardless of ethnicity.

The JScreen panel includes disease genes that are common in the Ashkenazi , Sephardic, or Mizrahi populations. Depending on the family’s country of origin, you may need additional testing. You can learn more at http://www.jewishgeneticdiseases.org/jewish-genetic-diseases. If you need a referral to a genetic counselor in your area for additional testing, please contact us.
Ashkenazi Jews are Jews whose ancestors came from Eastern and Central Europe. About 85% of the Jewish population in the United States is Ashkenazi. Sephardic/Mizrahi Jews have ancestors who came from North African and Mediterranean countries.
Yes. JScreen’s panel includes more than 100 genetic diseases that are commonly found in both the Jewish and general populations.
We do not recommend carrier screening on children. If your children are 18 or older, screening is available. It is important that your children be tested for the exact same genetic change (mutation) that you carry. Please email genetic.counselor@jscreen.org to schedule a genetic counseling session over the phone to discuss appropriate screening. It would help to have a copy of your results with you when you call. Alternatively, you can send us a copy of the results prior to calling by faxing them to 404-778-8642.
The JScreen test screens for all of the disease genes at the same time using what is called ‘chip technology.’ You do not need to specify which tests to run because they all run at the same time. The cost of the test is the same regardless of the number of diseases on the panel.
Individuals screened through Dor Yeshorim do not receive copies of their results. Dor Yeshorim results are only used to determine whether you and your partner carry the same disease gene and are therefore at risk for having children with that disease. If you screen through JScreen, you will receive copies of your results and will know your carrier status for each disease on the panel. Dor Yeshorim screens for fewer diseases than JScreen. Please contact their program for more specific information.
You can be screened through our program; however, please remember that results usually take about four weeks. For this reason, we strongly recommend that you and your partner get screened at the same time.
JScreen may be the right test for you. It depends on whether the specific genetic changes in your relative’s gene are testable through our panel. Try to find out if your relative has had a genetic (DNA) test and get a copy of their results, if available. Then contact us at genetic.counselor@jscreen.org to schedule a genetic counseling session over the phone to discuss appropriate screening.
Carrier testing is designed for people who are planning a family and wish to know if they are at increased risk to have a child with a genetic condition. It is not designed to provide information about personal health or to diagnose a person with symptoms. It cannot provide information about ancestry. People in the age range of 18-45 are most likely to be planning a family. People who are outside of this age range who believe they have reason to pursue JScreen testing should contact our office at 404-778-8640 or support@jscreen.org.

About the Results

Unfortunately, no genetic test is perfect and no screening test can eliminate all of your risk. A person can test negative for any of the disease genes and yet still be a carrier. JScreen’s tests, however, are designed specifically to reduce your risk.
No, carriers will not develop the disease. For the conditions on our screening panels, a person must have two copies of the gene, one from each parent, to have the condition.
Yes. Although the chance is very small, it is possible to learn, for example, that you have a late-onset form of either Gaucher disease or Tay Sachs disease. Should this happen, a genetic counselor will provide you with information about the condition and refer you to a medical specialist in your area.
Results will be available in four weeks or less.
You will receive an email indicating that your results are ready. This email will give you further instructions on how to obtain your results.
JScreen genetic counselors are able to use secure video conferencing to discuss results. We also have a national network of genetic counselors and will refer you to someone in your area for one-on-one counseling. If there is no one in your area, we may refer you to a genetic counselor that provides counseling using telehealth technology. Please note that genetic counseling sessions with non-JScreen counselors are not complimentary, and you will likely be charged a fee.
Yes, when you register for your testing, you will have the opportunity to indicate that you want a copy of your report sent to your family physician. If you’ve already received your results, complete this form to provide authorization for JScreen to release your results to your doctor. After we review your request, your doctor should receive your results within three business days. You can fax your completed form to 404-778-8642, or email it to support@jscreen.org.
We are not able to share confidential information with anyone other than the participant without his or her written permission. Please have your son/daughter contact us directly at support@jscreen.org.

Genetic Testing Cost

$99 if you have private health insurance. If the entire cost of the test is covered by insurance, the program fee will not be returned.
There is no extra cost for Fragile X syndrome testing.
Yes. If you do not have medical insurance, send an email to support@jscreen.org to get more information on the self-pay rate.

Yes, we do have limited financial assistance for those who cannot afford to pay. Send an email to support@jscreen.org for more information on availability.

There is no charge for your phone counseling session. If your counselor feels that you require more than the allotted time to discuss your results, he or she may refer you to a genetic counselor in your area for follow-up. This follow-up genetic counseling will likely result in a separate fee.

JGIFT Certificates

It’s easy! They simply need to request a kit through Jscreen.org. During the registration process, there’s a place for them to enter the number on their gift certificate(s).
For individuals with private health insurance, the gift certificate will cover the entire out-of-pocket (OOP) cost for the test. If a recipient does not have insurance or chooses not to use insurance, the value of the gift certificate will be applied to reduce their OOP expenses. The recipient will be billed for the balance owed.
Yes. Unused JScreen certificates expire five years after the date of purchase.
If a recipient receives more gift certificates than they need to cover their out-of-pocket expenses, they may transfer them to their partner, a friend, or a family member. Our goal is to screen as many people as possible!
If a recipient’s out-of-pocket expenses are less than the value of the gift certificate, any leftover funds will be used for JScreen’s financial assistance, outreach and education programs. Leftover funds will not be returned to the purchaser.

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